This viral infection depends on the entry of the virus through the host to replicate. Cardiovascular complications and focus of ACE2 as a co-receptor for SARS-CoV-2 are essential in this regard. Several patients exhibited cardiovascular-related pathologies, including Congestive Heart Failure (CHF) and cardio-respiratory medullary cardiac dysfunction. The leading cause of death from COVID-19 in the elderly and those with compromised immune systems is respiratory failure. Characteristics of SARS-CoV-2 with influenza are the higher transmission rates and the greater risk of death from COVID-19, mainly due to Acute Respiratory Distress Syndrome (ARDS). The rapid and progressive spread of the SARS-CoV-2 virus pandemic caused by the coronavirus (COVID-19) has severely affected thousands of people's health, the world's health system and has had a significant impact on the global economy.
However, both isolates did not show good interaction to 3CLPro, nsp12, and Spike protein of SARS CoV-2.
Predicted has good interaction to PLPro of SARS CoV-2 PLpro. The isolate trans-isoferulic acid predicted has good interaction to arginase. Antioxidant by FRAP methods KC4.4.6: 16,4 FeEAC mol/g and KC4.4.5.1: 15,79 FeEAC mol/g. The chemical constituent: KC4.4.6 ((-)-2-(E)-caffeoyl-D-glyceric acid) and KC4.4.5.1 (trans-isoferulic acid) have an arginase inhibitory activity KC4.4.6: 98,03 μg/ml and KC4.4.5.1: 292,58 μg/ml. The total phenols 723.61 mg GAE/gr, total flavonoids content 28.96 mg QE/gr extract. The methanol extract has IC 50 2.787 μg/ml for arginase inhibitory activity and IC 50 4,199 μg/ml for DPPH scavenging activity. This active extract was determined for its arginase inhibitory and antioxidant activity, determined the total phenols and total flavonoids, and identified chemical compound. The most active extract was methanol extract. This study aimed to investigate the arginase inhibitory and antioxidant activity of the chemical constituent of Sterculia comosa (wall) Roxb and also their binding affinities to arginase. The Sterculia genus has phenols and flavonoids content.
Flavonoids and phenols have an arginase inhibitory and antioxidant activity.
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